N. 143/2019 - 352164-2019 Gelieve hieronder de geselecteerde Europese overheidsopdracht te vinden.

donderdag 25 april 2024
Gelieve hieronder de geselecteerde Europese overheidsopdracht te vinden.
N. 143/2019 - 352164-2019
Publicatiedatum:26/07/2019
Uiterste datum:
 
Type:Enuntiatieve aankondiging
Land:NL
Onderwerp:
Onderzoeksdiensten
Aanbestedende overheid:
Wageningen University and Research 09215846
CPV-classificatie (gemeenschappelijke woordenlijst overheidsopdrachten):
79720000
Beschrijving:
Onderzoeksdiensten.

AFDELING: AANBESTEDENDE DIENST

Wageningen University and Research 09215846 Postbus 59 Wageningen 6700 AB Jasper Verkuilen _hidden_@wur.nl http://www.wur.nl https://platform.negometrix.com/PublishedTenders.aspx?tenderid=129182 onderzoek en onderwijs

RFI Marmoset Study

This request for information (RFI) is meant to support a possible tender for conducting a vaccine safety test for Wageningen University and Research (WUR).

The purpose of this RFI is to give contract research organizations who can meet the required specifications the opportunity to express interest in performing the studies.

This request for information (RFI) is meant to support a possible tender for conducting a vaccine safety test for Wageningen University and Research (WUR).

The purpose of this RFI is to give contract research organizations who can meet the required specifications the opportunity to express interest in performing the studies.

Rift Valley fever is a mosquito-borne disease that affects domesticated and wild ruminants, of which sheep are the most susceptible. The disease is caused by Rift Valley fever virus (RVFV). Infection of new-born lambs generally results in mortality and infection of pregnant ewes in abortion. Humans can be infected via the bites of mosquitoes or via contact with animal tissues or fluids released during the slaughtering of diseased animals. The virus is not contagious. Infections of humans generally manifest as a self-resolving flu-like illness, whereas a small percentage of individuals develop severe complications that may be fatal. WUR has developed an attenuated form of RVFV, which was shown to be completely safe for even the most susceptible target animals and to provide complete protection after a single vaccination (Wichgers Schreur et al., 2014, 2015, 2017, several manuscripts in preparation). Due to its strong attenuation, this live-attenuated vaccine may be handled at biosafety level 2 (BSL2) in the Netherlands. WUR aims to evaluate the use of this technology to develop a live-attenuated human vaccine. Before the safety of this vaccine can be evaluated in human volunteers, the safety of the vaccine has to be demonstrated in a suitable animal model. The present project will address the safety of the vaccine for common marmosets (Callithrix jacchus). The study will start with a pilot experiment (2 marmosets) with a duration of 28 days, followed by a study with 18 animals (3 groups of 6 animals) with a duration of 50 days. One group will be housed in BSL3 containment. Blood samples (n=16/animal) will be collected for serology, clinical chemistry and hematology. The in-life phase will be followed with necropsy and collection of 24 organ samples per animal. AAALAC accreditation is required.

Vermoedelijke datum van de bekendmaking van de aankondiging van een opdracht: 2019-11-30

AFDELING: PROCEDURE

AFDELING: AANVULLENDE INLICHTINGEN

Datum van verzending van deze aankondiging: 2019-07-24


Tekst in originele taal
 
 AFDELING: AANBESTEDENDE DIENST 
 Wageningen University and Research 09215846 Postbus 59 Wageningen 6700 AB Jasper Verkuilen _hidden_@wur.nl http://www.wur.nl https://platform.negometrix.com/PublishedTenders.aspx?tenderid=129182 onderzoek en onderwijs 
RFI Marmoset Study
 
This request for information (RFI) is meant to support a possible tender for conducting a vaccine safety test for Wageningen University and Research (WUR).
The purpose of this RFI is to give contract research organizations who can meet the required specifications the opportunity to express interest in performing the studies.
 
This request for information (RFI) is meant to support a possible tender for conducting a vaccine safety test for Wageningen University and Research (WUR).
The purpose of this RFI is to give contract research organizations who can meet the required specifications the opportunity to express interest in performing the studies.
Rift Valley fever is a mosquito-borne disease that affects domesticated and wild ruminants, of which sheep are the most susceptible. The disease is caused by Rift Valley fever virus (RVFV). Infection of new-born lambs generally results in mortality and infection of pregnant ewes in abortion. Humans can be infected via the bites of mosquitoes or via contact with animal tissues or fluids released during the slaughtering of diseased animals. The virus is not contagious. Infections of humans generally manifest as a self-resolving flu-like illness, whereas a small percentage of individuals develop severe complications that may be fatal. WUR has developed an attenuated form of RVFV, which was shown to be completely safe for even the most susceptible target animals and to provide complete protection after a single vaccination (Wichgers Schreur et al., 2014, 2015, 2017, several manuscripts in preparation). Due to its strong attenuation, this live-attenuated vaccine may be handled at biosafety level 2 (BSL2) in the Netherlands. WUR aims to evaluate the use of this technology to develop a live-attenuated human vaccine. Before the safety of this vaccine can be evaluated in human volunteers, the safety of the vaccine has to be demonstrated in a suitable animal model. The present project will address the safety of the vaccine for common marmosets (Callithrix jacchus). The study will start with a pilot experiment (2 marmosets) with a duration of 28 days, followed by a study with 18 animals (3 groups of 6 animals) with a duration of 50 days. One group will be housed in BSL3 containment. Blood samples (n=16/animal) will be collected for serology, clinical chemistry and hematology. The in-life phase will be followed with necropsy and collection of 24 organ samples per animal. AAALAC accreditation is required.
 Vermoedelijke datum van de bekendmaking van de aankondiging van een opdracht: 2019-11-30 
 AFDELING: PROCEDURE 
 
 AFDELING: AANVULLENDE INLICHTINGEN 
Datum van verzending van deze aankondiging: 2019-07-24